Experimental evaluation of the effectiveness of polysorb, glycine and sodium dithionite in acute severe ethanol poisoning
https://doi.org/10.25016/2541-7487-2015-0-1-90-95
Abstract
Effectiveness of agents (polysorb, glycine and sodium dithionite) influencing the main elements of ethanol toxicokinetics was compared in terms of three-day survival, neurological status, and some vital signs in 35 rats with acute ethanol intoxication at extremely heavy dose of 1.5 LD50 (12 g/kg). Ethanol as 40 % solution was administered intragastrically. Polysorb was administered intragastrically at a dose of 2000 mg/kg, glycine – intraperitoneally at a dose of 12 mg/kg, and sodium dithionite – intraperitoneally at a dose of 10 mg/kg. Preparations were administered (15 min after alcohol) separately or in combination. It was established that polysorb and sodium dithionite are the most effective as monotherapy; time to coma onset was twice as much as compared with the control group. Combination therapy with the study drugs reduced the number of animals in the terminal coma by 50 %, increased the time to onset of sopor and superficial coma two-fold, positively influenced respiratory rate of poisoned rats.
About the Authors
A. A. Khovpachev
Kirov Military Medical Academy
Russian Federation
Russian Federation
Student, Kirov Military Medical Academy (Russia, 194044, Saint-Petersburg, Academica Lebedeva Str., 6)
D. A. Halyutin
Kirov Military Medical Academy
Russian Federation
Russian Federation
PhD Student of the Department of Military Toxicology and Medical Defense, Kirov Military Medical Academy (Russia, 194044, Saint-Petersburg, Academica Lebedeva Str., 6)
V. L. Reiniuk
Kirov Military Medical Academy
Russian Federation
Russian Federation
Dr. Med. Sci., Prof. of the Department of Military Toxicology and Medical Defense, Kirov Military Medical Academy (Russia, 194044, Saint-Petersburg, Academica Lebedeva Str., 6)
E. V. Davydova
Kirov Military Medical Academy
Russian Federation
Russian Federation
PhD Med. Sci., Associate Prof. of the Department of Military Toxicology and Medical Defense, Kirov Military Medical Academy (Russia, 194044, Saint-Petersburg, Academica Lebedeva Str., 6)
A. N. Grebenyuk
The Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Kirov Military Medical Academy
Russian Federation
Russian Federation
Dr. Med. Sci. Prof., Rector of the Institute of Additional Professional Education, The Nikiforov Russian Center of Emergency and Radiation Medicine of EMERCOM of Russia (Russia, 194044, Saint-Petersburg, Academica Lebedeva Str., 4/2), Prof. of the Department of Military Toxicology and Medical Defense, Kirov Military Medical Academy (Russia, 194044, Saint-Petersburg, Academica Lebedeva Str., 6)
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Review
For citations:
Khovpachev A.A., Halyutin D.A., Reiniuk V.L., Davydova E.V., Grebenyuk A.N. Experimental evaluation of the effectiveness of polysorb, glycine and sodium dithionite in acute severe ethanol poisoning. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2015;(1):90-95. (In Russ.) https://doi.org/10.25016/2541-7487-2015-0-1-90-95
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