Experimental evaluation of neurotoxic effects of ethanol and their correction by peptide preparations
https://doi.org/10.25016/2541-7487-2014-0-3-70-77
Abstract
In experiments on inbred rats neurotoxic effects of ethanol developing at acute severe intoxication by ethanol and comparative evaluation of effectiveness of peptide preparations molixan and semax as means of correction of these violations are studied. The central nervous system function (motor and research performance, decision-making speed, ability to dimensional orientation, a condition of search and research activity, physical endurance) studied by techniques «open field», «a cruciform labyrinth», «a vertical core» on 2, 5, 7 and 14 days after ethanol introduction. 40 % ethanol was administrated per os in dose 1.5 LD50 (12 g/kg), semax - intranasal in a single dosage of 3 mg/kg, molixan was injected intraperitoneum in a single dosage of 30 mg/kg. It was used treatment and prophylactic scheme of application of preparations (in 1 h prior to and right after ethanol introduction). It was established that ethanol causes in rats violation of motor, research and search performance, speed of a decision-making, dimensional orientation and physical endurance within two weeks after intoxication beginning. Application of molixan, semax and their combinations improved restitution of the central nervous system functions caused by ethanol intoxication. Drunkenness monotherapy of semax or molixan and the combined therapy by collateral application of both preparations did not differ by efficiency from each other.
About the Authors
A. N. Grebenyuk
The Kirov Military Medical Academy
Russian Federation
Dr. Med. Sci. Prof., Head of the Department of Military Toxicology and Medical Defense
Russian Federation
Dr. Med. Sci. Prof., Head of the Department of Military Toxicology and Medical Defense
V. L. Reinyuk
The Kirov Military Medical Academy
Russian Federation
Dr. Med. Sci., Assistant Prof. of the Department of Military Toxicology and Medical Defense
Russian Federation
Dr. Med. Sci., Assistant Prof. of the Department of Military Toxicology and Medical Defense
D. A. Khalyutin
The Kirov Military Medical Academy
Russian Federation
postgraduate student of the Department of Military Toxicology and Medical Defense
Russian Federation
postgraduate student of the Department of Military Toxicology and Medical Defense
E. V. Davydova
The Kirov Military Medical Academy
Russian Federation
PhD Med. Sci., Assistant Prof. of the Department of Military Toxicology and Medical Defense
Russian Federation
PhD Med. Sci., Assistant Prof. of the Department of Military Toxicology and Medical Defense
A. A. Khovpachev
The Kirov Military Medical Academy
Russian Federation
student
Russian Federation
student
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For citations:
Grebenyuk A.N., Reinyuk V.L., Khalyutin D.A., Davydova E.V., Khovpachev A.A. Experimental evaluation of neurotoxic effects of ethanol and their correction by peptide preparations. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2014;(3):70-77. (In Russ.) https://doi.org/10.25016/2541-7487-2014-0-3-70-77
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