Risk Factors for Carotid Atherosclerosis in Managerial Specialists of EMERCOM of Russia
https://doi.org/10.25016/2541-7487-2014-0-4-52-59
Abstract
Thickness of carotid intima-media complex and occurrence of carotid plaques are established important biomarkers of subclinical atherosclerosis, and they are associated with many cardiovascular risk factors. However, the impact of different risk factors on vascular structure is still not well understood. We studied 88 managerial specialists of EMERCOM of Russia with high psychosocial work stress and 32 control patients, aged 34-65. Patients underwent neuropsychological assessment to evaluate the level of work stress. B-mode carotid ultrasonography was used to assess the presence of carotid plaques and the carotid intima-media thickness. Complex laboratory diagnostics included lipid profile, values of apolipoprotein A, apolipoprotein B, glucose, high sensitivity C-reactive protein (hs-CRP), homocysteine. The major risk factors for carotid atherosclerosis appeared to be older age, work stress (mainly due to the lack of days off), high hs-CRP, and reduced level of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein ratio.
About the Authors
V. V. Kindyashova
The Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Head of the Research Laboratory, Department of Clinical Neurology
Russian Federation
Head of the Research Laboratory, Department of Clinical Neurology
O. V. Tikhomirova
The Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Dr. Med. Sci., Head of the Department of Clinical Neurology
Russian Federation
Dr. Med. Sci., Head of the Department of Clinical Neurology
N. N. Zybina
The Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Dr. Biol. Sci. Prof., Head of the Department of Laboratory Diagnostic
Russian Federation
Dr. Biol. Sci. Prof., Head of the Department of Laboratory Diagnostic
V. V. Kozhevnikova
The Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Researcher, Department of Clinical Neurology
Russian Federation
Researcher, Department of Clinical Neurology
V. N. Vasil’ev
The Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Neurologist, Department of Clinical Neurology
Russian Federation
Neurologist, Department of Clinical Neurology
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For citations:
Kindyashova V.V., Tikhomirova O.V., Zybina N.N., Kozhevnikova V.V., Vasil’ev V.N. Risk Factors for Carotid Atherosclerosis in Managerial Specialists of EMERCOM of Russia. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2014;(4):52-59. (In Russ.) https://doi.org/10.25016/2541-7487-2014-0-4-52-59
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