Analysis of hormonal changes that contribute to accelerated aging of Chernobyl accident consequences liquidators after 18 and 28 years
https://doi.org/10.25016/2541-7487-2016-0-1-51-61
Abstract
Clinical and laboratory indicators of the neuroendocrine system were analyzed along with the phenomenon of premature aging and androgen status in 68 male liquidators of the accident at the Chernobyl nuclear power plant aged (48.0 ± 1.2) 18 years after the accident and 56 liquidators aged (67.2 ± 8.8) 28 years after the accident with a fixed radiation dose from 20 to 125 cGy as per accounting cards. Biological age was defined via the method of the Institute of Gerontology, Academy of Medical Sciences of the USSR, based on clinical and instrumental examinations. The control group consisted of 19 men without history of radiation exposure and other occupational hazards. According to assessments, subgroups with the biological age of 60 years and over 60 years were identified. By passport age, these subgroups did not differ significantly. With increasing biological age and index of premature aging, hormonal imbalance (decreased testosterone, free androgen index, prolactin, DHEAS, increased cortisol, disrupted negative feedback) typical for physiologic were revealed in Chernobyl cleanup workers. In 28 years after the accident, these changes became more pronounced.
About the Authors
N. A. Alhutova
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Russian Federation
PhD Biol. Sci., Senior Research Associate Laboratory of serology and allergology, the Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia (Russia, 194044, St. Petersburg, Academica Lebedeva Str., 4/2)
N. A. Kovyazina
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Russian Federation
PhD Med. Sci., Head of the Laboratory of serology and allergology, the Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia (Russia, 194044, St. Petersburg, Academica Lebedeva Str., 4/2)
N. N. Zybina
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Russian Federation
Dr. Biol. Sci. Prof., Head of Clinical Laboratory Department of the Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia (Russia, 194044, St. Petersburg, Academica Lebedeva Str., 4/2)
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Review
For citations:
Alhutova N.A., Kovyazina N.A., Zybina N.N. Analysis of hormonal changes that contribute to accelerated aging of Chernobyl accident consequences liquidators after 18 and 28 years. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2016;(1):64-70. (In Russ.) https://doi.org/10.25016/2541-7487-2016-0-1-51-61
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