The role of the syndrome of chronic adaptive overstrain in the pathogenesis of wound disease

Relevance. More than 13.2 million injuries are recorded every year in Russia. For example, in 2005–2015 the level of injuries among the population of Russia was 92 ‰. Severe and combined injuries can be complicated by traumatic disease, which often occurred in the military when conducting combat operations.
Intention.To present the mechanism of chronic adaptive overstrain syndrome in the pathogenesis of wound disease.
Methodology. Wound disease is a special case of a traumatic disease, with an open wound with disrupted integrity of the skin and adjacent internal organs due to traumatic factors. The basis of the material was the author’s research on the study of chronic adaptive overstrain syndrome in 2500 servicemen of the Soviet Army in combat operations in the Republic of Afghanistan in 1979–1989.
Results and Discussion. In contrast to a traumatic disease of peacetime, wound disease in a war is accompanied by impaired functional reserves in the form of an adaptive (environmental-occupational) stress syndrome due to “disturbing” combat stress factors. The main manifestations of chronic adaptive overstrain syndrome in military personnel are decreased body resistance to banal infections; high infectious morbidity throughout the year, regardless of the season; the growth of areactive forms of infectious diseases against the background of allergization; chronic inflammatory and recurrent processes; low rates of wound and other injuries healing; high frequency of infectious complications in the treatment of wounds; a significant weakening of the bactericidal properties of the skin; frequent occurrence of reactive arthritis in diseases for which joint damage is not typical.
Conclusion. Extreme military factors result in depletion of the functional and structural reserve of compensatory processes of the body, with a state of pre-disease and complicated wound healing. Thus, initial manifestations of chronic adaptive overstrain syndrome due to combat stress in soldiers should be corrected as soon as possible. 

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