Cerebral neurological complications in patients with thermal injury
https://doi.org/10.25016/2541-7487-2017-0-1-77-83
Abstract
Relevance. Treatment of patients with severe thermal injury includes therapy comorbidities and complications, among which the special role played by the central nervous system. Their development is largely determines the weighting of the condition worsens the prognosis, as well as leading the timing of recovery. For burn disease may be accompanied by the development of the cerebral neurological complications, such as burn encephalopathy, acute violation of cerebral circulation, secondary purulent meningitis. Intention – identify the main pathogenetic mechanisms of neurologic complications and their correction have burned. Methods Review and analysis of literature data on neurological complications from burned and their treatment options. Results and Discussion. In the genesis of neurological disorders in the burned main role constitute the hemodynamic, electrolyte disorders, violations, breach the blood-brain barrier in the face of intoxication. Develops complex disorders, which can result in secondary purulent meningitis and meningoencephalitis. A comprehensive treatment, including surgical restoration of the skin integument, infusion therapy, antibiotics, drugs neuroprotektors stimulants avoids a number of severe complications. Conclusion. Timely pathogenetically justified treatment of neurological complications in burned, carried out within the framework of the integrated therapy of burn disease is essential, because such an approach contributes to the best possible outcomes.
About the Authors
Sergey Vladimirovich VorobievRussian Federation
Dr. Med. Sci., Senior Lecturer, Department of nervous diseases
Aleksandr Leonidovich Admakin
Russian Federation
PhD Med. Sci., Associate Prof., Department of Thermal Lesions
Andrey Sergeevich Titov
Russian Federation
PhD Med. Sci., Chief of Anesthesiology, resuscitation and intensive therapy clinic Thermal Lesions and plastic surgery
References
1. Admakin A.L. Sovershenstvovanie infuzionno-transfuzionnoi terapii ozhogovogo shoka [Improvement of infusion-transfusion therapy of burn shock] : Abstract dissertation PhD Med. Sci.. Sankt-Peterburg. 2003. 23 p.
2. Airiyan N.Yu., Anisimov N.V., Burov S.A. [et al.]. Gemorragicheskii insul’t Hemorrhagic stroke]. Eds.: V.I. Skvortsova, V.V. Krylov. Moskva. 2005. 155 p.
3. Afanas’ev V.V., Luk’yanova I.Yu., Barantsevich E.R. Farmakologiya i klinicheskoe primenenie kholinotropnykh sredstv presinapticheskogo deistviya [Pharmacology and clinical use of holinotropnyh funds presinapticheskogo actions]. Sankt-Peterburg. 2011. 133 p.
4. Badalyan L.O., Chekhonin V.P., Bembeeva R.Ts. Spetsificheskie belki nervnoi tkani v otsenke pronitsaemosti gematoentsefalicheskogo bar’era pri komatoznykh sostoyaniyakh u detei [Specific proteins of neural tissue in the evaluation of blood-brain barrier permeability in comatose conditions in children]. Zhurnal nevropatologii i psikhiatrii im. S.S. Korsakova [S.S. Korsakov Journal of Neurology and Psychiatry]. 1997. Vol. 97, N 1. Pp. 41–46.
5. Ben’kovich B.I. Sostoyanie nervnoi sistemy pri ozhogovoi bolezni. Voenno-meditsinskii zhurnal. 1975. N 3. Pp. 47–49.
6. Bogachenko V.P. Nervno-psikhicheskie narusheniya pri ozhogovoi bolezni: (klinicheskii aspekt problemy) [Neuro-psychiatric disorders in burn disease: (clinical aspect of the problem)] : Abstract dissertation Dr. Med. Sci. Leningrad. 1964. 16 p.
7. Bolezni nervnoi sistemy [Diseases of the nervous system]: in 2 Vol. Eds.; N. N. Yakhno, D.R. Shtul’man. Moskva. 2001. Vol. 2. 480 p.
8. Vein A.M., Voznesenskaya T.G., Vorob’eva O.V. [et al.]. Vegetativnye rasstroistva: klinika, diagnostika, lechenie [Autonomic disorders]. Moskva. 2003. 752 p.
9. Voloshin P.V. Patologiya nervnoi sistemy pri ozhogovoi bolezni [Pathology of the nervous system in burn disease]. Kiev. 1982. 143 p.
10. Voronina T.A. Meksidol: osnovnye neiropsikhotropnye effekty i mekhanizmy deistviya [Mexidol: basic nejropsihotropnye effects and mechanisms of action]. Farmateka [Pharmateca]. 2009. N 6. Pp. 28–31.
11. Gel’fand V.B., Tumanov V.P., Malamud M.D., Nikolaev G.V. K voprosu ob ozhogovoi entsefalopatii [The issue of burn encephalopathy]. Zdravookhranenie [Health]. Kishinev. 1983. N 2. Pp. 15.
12. Gerasimova M.M., Kondrat”ev G.P. Kliniko-immunologicheskie osobennosti tserebral’nykh rasstroistv pri termicheskoi travme [Clinical and immunological features of cerebral disorders in thermal injury]. Nevrologocheskii vestnik. Zhurnal imeni V.M. Bekhtereva [Neurological bulletin. Named after V.М. Bekhterev]. 2005. Vol. XXXVII, Issue 1/2. Pp. 32–34.
13. Gizatullin T.R., Zinatullin R.M., Khunafin S.N. [et al.]. Sposob otsenki techeniya ozhogovoi bolezni v razlichnye periody s uchetom psikhosomaticheskogo sostoyaniya bol’nykh s termicheskoi travmoi : patent na izobretenie N 2480148 RU. MPI A61B 5/00, zayavleno 2012108279/14, 05.03.2012 ; opublikovano 27.04.2013, Byulleten’ 12 [Newsletter].
14. Gusev E.I., Skvortsova V.I. Ishemiya golovnogo mozga [Brain ischemia]. Moskva. 2001. 328 p.
15. Insul’t: diagnostika, lechenie, profilaktika [Stroke: diagnosis, treatment, prevention]. Eds.: Z.A. Suslina, M.A. Piradov. 2nd edition. Moskva. 2009. 288 p.
16. Kovtun O.P., L’vova O.A. Ozhogovaya entsefalopatiya – sovremennye podkhody k diagnostike i lecheniyu (obzor literatury) [Burn encephalopathy-modern approaches to diagnostics and treatment (review of literature)]. Vestnik Ural’skoi med-itsinskoi akademicheskoi nauki [Bulletin of Ural medical academic science]. 2007. N 2. Pp. 145–149.
17. Kozinets G.P., Slesarenko S.V., Radzikhovskii A.P. [et al.]. Ozhogovaya intoksikatsiya: patogenez, klinika, printsipy lecheniya [Burn intoxication: pathogenesis, clinic, treatment guidelines]. Moskva. 2005. 24 p.
18. Kondrat’ev G.P., Kondrat’ev P.A., Gerasimova M.M. Sposob prognozirovaniya stepeni tyazhesti tserebral’nykh rasstroistv pri termicheskoi travme : patent na izobretenie N 2292556 RU. MPI A61B 5/00, zayavleno 2005121072/15, 05.07.2005 ; opublikovano 27.01.2007, Byulleten’ 3 [Method of forecasting the severity of cerebral disorders in thermal injury]
19. Kondrat’ev G.P. Kliniko-immunologicheskie osobennosti tserebral’nykh rasstroistv pri termicheskoi travme [Clinical and immunological features of cerebral disorders in thermal injury] : Abstract dissertation PhD Med. Sci. Moskva. 2006. 14 p.
20. Levin O.S. Diagnostika i lechenie dementsii v klinicheskoi praktike [Diagnosis and treatment of dementia in clinical practice]. Moskva. 2010. 256 p.
21. Litvinenko I.V., Vorob’ev S.V., Lobzin V.Yu., Lupanov I.A. Vozmozhnosti farmakologicheskoi modulyatsii tserebral’noi glutamatergicheskoi sistemy v terapii sosudistykh kognitivnykh narushenii [Possibility of pharmacological modulation of cerebral glutamatergicheskoj system in therapy of vascular cognitive impairment]. Zhurnal nevrologii i psikhiatrii im. S.S. Korsako-va [S.S. Korsakov Journal of Neurology and Psychiatry]. 2013. Vol. 113, N 9. Pp. 29–35.
22. Lobzin Yu.V., Pilipenko V.V., Gromyko Yu.N. Meningity i entsefality [Meningitis and encephalitis]. Sankt-Peterburg. 2003. 128 p.
23. Nevrologiya [Nevrology]. Eds.: Gusev E.I., Konovalov A.N., Skvortsova V.I., Gekht A.B. Moskva. 2010. 1040 p.
24. Nechipurenko N.I., Pashkovskaya I.D., Musienko Yu.I. Osnovnye patofiziologicheskie mekhanizmy ishemii golovnogo mozga [The basic pathophysiological mechanisms of cerebral ischemia]. Meditsinskie novosti [Medical news]. 2008. N1. Pp. 7–13.
25. Odinak M.M., Emelin A.Yu., Lobzin V.Yu., Vorob’ev S.V. Vozmozhnosti medikamentoznoi korrektsii funktsional’nykh narushenii pri postgipoksicheskoi entsefalopatii [Possible drug correction of functional disorders with postgipoksicheskoj encephalopathy]. Nevrologiya, neiropsikhiatriya, psikhosomatika [Neurology, neuropsychiatry, psychosomatics]. 2012. N 2. Pp. 83–87.
26. Odinak M.M., Voznyuk I.A. Narusheniya krovoobrashcheniya golovnogo mozga [Circulatory disorders of the brain]. Sankt-Peterburg. 2002. 80 p.
27. Rumyantseva S.A., Bolevich S.B., Silina E.V., Fedin A.I. Antioksidantnaya terapiya gemorragicheskogo insul’ta [Antioxidant therapy of hemorrhagic stroke]. Moskva. 2007. 70 p.
28. Saakov B.A. Termicheskaya travma i nervnaya sistema [Thermal injury and nervous system] : Abstract dissertation Dr. Med. Sci. Rostov-na-Donu. 1962. 40 p.
29. Sorokina E.Yu., Buryak T.A., Leshchev D.P. Ozhogovaya entsefalopatiya kak proyavlenie organnoi disfunktsii pri tyazheloi termicheskoi travme [Burn encephalopathy as a manifestation of organ dysfunction in severe thermal injury]. Vestnik neotlozhnoi i vosstanovitel’noi meditsiny [Bulletin of urgent and recovery medicine]. 2014. Vol. 15, N 1. Pp. 34–38.
30. Sorokina M.N., Skripchenko N.V., Ivanova V.V. [et al.]. Meningokokkovaya infektsiya u detei [Meningococcal disease in children]. Sankt-Peterburg. 2000 56 p.
31. Fedin A.I., Rumyantseva S.A. Izbrannye voprosy bazisnoi intensivnoi terapii narushenii mozgovogo krovoobrashcheniya [Selected issues of basic intensive therapy of cerebral circulation]. Moskva. 2002. 256 p.
32. Khrulev S.E., Belova A.N., Bulyubash I.D. [et al.]. Profilaktika i lechenie porazhenii golovnogo mozga pri ozhogovoi bolezni [Prevention and treatment of brain lesions in burn disease]. Nizhegorodskii meditsinskii zhurnal [Nizhegorodsky medical journal]. 2002. N 3. Pp. 55–60.
33. Khrulev S.E. Ozhogovaya travma s tserebral’nymi oslozhneniyami u vzroslykh i detei (klinika, mekhanizmy razvitiya, profilaktika) [Burn injury with cerebral complications in adults and children] : Abstract dissertation Dr. Med. Sci. Nizhnii Novgorod. 2009. 34 p.
34. Khrulev S.E. Patogenez, klinika i profilaktika tserebral’nykh oslozhnenii ozhogovoi travmy [Англ. перевод названия]. Kombustiologiya [Pathogenesis, clinic and prevention of cerebral complications of burn injury] : electronic journal. 2010. N 41. URL: http://combustiolog.ru/journal/.
35. Yakhno N.N., Zakharov V.V., Lokshina A.B. [et al.]. Dementsii [Dementia]. Moskva. 2011. 272 p.
36. Fogelholm R., Palomaki H., Erila T. [et al.]. Blood pressure, nimodipine, and outcome of ischemic stroke. Acta Neuro-logica Scandinavica. 2004. Vol. 109, N 3. Pp. 200–204.
37. Hartbauer M., HutterPaier B., Skofitsch G., Windisch M. Antiapoptotic effects of the peptidergic drug Cerebrolysin on primary cultures of embryonic chick cortical neurons. J. Neural. Transm. 2001. Vol. 108, N 4. Pp. 459–473.
38. Opal S.M. Insights into the immune dysfunction associated with thermal injury. Crit. Care Med. 2002. Vol. 30, N 7. Pp. 1651–1652.
39. Secades J.J. CDP-choline: update and review of its pharmacology and clinical use. Methods & Find. Exp. Clin. Phar-macol. 2002. Vol. 24, Supp. B. Pp. 1–53.
40. Szilagyi G., Nagy Z., Balkay L. [et al.]. Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients: a PET study. Neurol. Sci. 2005. Vol. 229/230, N 1. Pp. 275—284.
41. Windisch M., Gschanes A., HutterPaier B. Neurotrophic activities and therapeutic experience with brain derived peptide preparation. J. Neural. Transm. 1998. Vol. 53, Supp. 1. Pp. 289–298.
Review
For citations:
Vorobiev S.V., Admakin A.L., Titov A.S. Cerebral neurological complications in patients with thermal injury. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2017;(1):77-83. (In Russ.) https://doi.org/10.25016/2541-7487-2017-0-1-77-83