Evaluating the effectiveness of antidotal treatment of severe carbon monoxide poisoning under mechanical ventilation
https://doi.org/10.25016/2541-7487-2015-0-4-65-70
Abstract
Pathogenetic and clinical features of acute carbon monoxide poisoning complicated with airway thermochemical lesions were identified; this requires significant correction of diagnosis and treatment approaches. It is shown that if the patient cannot be placed in a hyperbaric resuscitation chamber during mechanical ventilation, treatment strategy can be based on Acyzol antidotal effect. With the introduction of Acyzol in the treatment regimens, carboxyhemoglobin reduced more rapidly with marked positive dynamics in the course of endobronchitis, frequency and severity of respiratory, cardiovascular and nervous complications decreased, as well as coma duration. As a result, duration of mechanical ventilation considerably reduced along with mortality, duration of intensive care and total length of hospitalization.
About the Authors
E. V. Polozova
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Dr. Med. Sci., Prof. of toxicology and emergency medicine, North-Western State Medical University named after I.I. Mechnikov (Russia, 191015, St. Petersburg, Kirochnaya Str., 41)
V. V. Shilov
North-Western State Medical University named after I.I. Mechnikov, The North-Western Research Centre for Hygiene and Public Health
Russian Federation
Russian Federation
Dr. Med. Sci. Prof., Head of department of toxicology and emergency medicine, North-Western State Medical University named after I.I. Mechnikov (Russia, 191015, St. Petersburg, Kirochnaya Str., 41), Director of the North-Western Research Centre for Hygiene and Public Health (Russia, 191036, St. Petersburg, 2nd Sovetskaya Str., 4)
A. S. Bogasheva
North-Western State Medical University named after I.I. Mechnikov, The North-Western Research Centre for Hygiene and Public Health
Russian Federation
Russian Federation
PhD Biol. Sci., senior lecturer of the Department of toxicology and emergency medicine, North-Western State Medical University named after I.I. Mechnikov (Russia, 191015, St. Petersburg, Kirochnaya Str., 41), Research Associate, the North-Western Research Centre for Hygiene and Public Health (Russia, 191036, St. Petersburg, 2nd Sovetskaya Str., 4)
E. V. Davydova
Kirov Military Medical Academy
Russian Federation
Russian Federation
PhD Med. Sci., Associate Prof., Department of military toxicology and medical protection, Kirov Military Medical Academy (Russia, 194044, St. Petersburg, Academica Lebedeva Str., 6)
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Review
For citations:
Polozova E.V., Shilov V.V., Bogasheva A.S., Davydova E.V. Evaluating the effectiveness of antidotal treatment of severe carbon monoxide poisoning under mechanical ventilation. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2015;(4):65-70. (In Russ.) https://doi.org/10.25016/2541-7487-2015-0-4-65-70
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