Character of biochemical changes in military men with different genotypes of metabolism regulator genes when performing tasks in extreme conditions

Changes of blood plasma biochemical values were assessed in 570 military men serving under contract and performing training-combat tasks in extreme conditions based on metabolism regulator genes polymorphism. Military men were (21.3 ± 2.4) years old, with body weight (82.2 ± 4.5) kg, energy expenditure (6635 ± 2001) kcal/70 (kg  day). Gene alleles TFAM, PPARA and PPARGC1A correlated with successful adaptation to high exercise load during training-combat tasks. Glucose, AST, lactate, unesterified fatty acids, BUN and creatinine were the most significant parameters of blood biochemistry for assessment of successful adaptation to high exercise loads. Biochemical changes recovered to baseline three days after load cessation in military men with alleles associated with aerobic metabolism predisposition in contrast to homozygous carriers of TFAM Ser, PPARA C and PPARGC1A Ser alleles in whom biochemical changes persisted longer and were significantly different from baseline. When assessing free blood amino acids during extreme loads, lysin, cystine, arginine, alanine, glutamic acid, valine, phenylalanine and leucine were the most significant: their concentrations increased 1.5–3 fold. In those with genotypic predisposition to aerobic metabolism these alterations recovered to baseline within three days, while for TFAM Ser/Ser, PPARA C/C and PPARGC1A Ser/Ser genotypes these changes persisted and were significantly different from baseline. Our results suggest the prevalence of catabolic reactions during extreme loads in groups with TFAM Ser/Ser, PPARA C/C and PPARGC1A Ser/Ser genotypes, which makes the rehabilitation more difficult and longer.

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