METABOLIC PROTECTORS IN COMPLEX THERAPY OF ORGANO-PHOSPHATE INTOXICATIONS
https://doi.org/10.25016/2541-7487-2013-0-1-84-89
Abstract
The purpose of investigation was to study defensive mechanisms of metaprot and ethomerzol (25 and 50 mg/kg) in a rat model of acute carbophos intoxication (256.0 ± 8.7) mg/kg. Both compounds recovered physical load tolerance, normalized the activity of aspartate and alanine transaminases, reduced bilirubine, creatinine and urea nitrogen levels. Effects on lipid peroxidation were reported as decreased malonic dialdehyde concentration and increased levels of reduced glutathione, as well as elimination of signs of endogenic intoxication. Antihypoxic, antioxidant, actoprotective, energotropic and reparative effects of metaprot and ethomerzol were proved.
About the Authors
V. V. Vorobieva
Kirov Military Medical Academy, Saint-Petersburg
Russian Federation
Russian Federation
I. V. Zarubina
Kirov Military Medical Academy, Saint-Petersburg
Russian Federation
Russian Federation
P. D Shabanov
Kirov Military Medical Academy, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Vorobieva V.V., Zarubina I.V., Shabanov P.D. METABOLIC PROTECTORS IN COMPLEX THERAPY OF ORGANO-PHOSPHATE INTOXICATIONS. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(1):66-73. (In Russ.) https://doi.org/10.25016/2541-7487-2013-0-1-84-89
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