INDICATORS OF TISSUE IMMUNITY IN DIFFERENT TYPES OF FLOW AND CLINICAL OUTCOME OF CHRONIC INFLAMMATION OF THE UPPER GASTROINTESTINAL TRACT
https://doi.org/10.25016/2541-7487-2013-0-1-60-65
Abstract
Study results on indicators of tissue immunity in patients with different variants of chronic gastritis, gastric polyps and neoplasia are presented. The ratio of lymphocyte subsets of the stomach mucous is characterized by a predominance of T lymphocytes and specific cytotoxic T lymphocytes. Count of B , NK cells and minor lymphocyte subsets is determined by patterns of the immune response in various pathological processes of the gastroduodenal zone.
About the Authors
N. I. Davydova
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Russian Federation
V. N. Bychkova
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Russian Federation
M. G. Kobiashvili
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Russian Federation
I. A. Mikhailova
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Russian Federation
References
1. Aruin L.I. Novaya mezhdunarodnaya klassifikatsiya displazii slizistoi obolochki zheludka [The new international classification of dysplasia of the gastric mucosa]. Rossiiskii zhurnal gastroenterologii, gepatologii i koloproktologii [The Russian Journal of Gastroenterology, Hepatology and Coloproctology]. 2002. N. 12. Pp. 15–17. (In Russ.)
2. Khaitov R.M., Ignat'eva G.A., Sidorovich I.G. Immunologiya [Immunology]. Moskva. 2000. 458 p. (In Russ.)
3. Tsimmerman Ya.S. Gastroenterologiya [Gastroenterology]. Moskva. 2012. 800 p. (In Russ.)
4. Yarilin A.A. Immunologiya [Immunology]. Moskva. 2010. 749 p. (In Russ.)
5. Blaser M.J. Helikobacter pylory and gastric disease. BMJ. 1998. Vol. 316, N 7143. Pp. 1507–1510.
6. Guarner J., Baetlett J., Seitz R. [et al.]. Cell proliferation and inflammation on biopsy samples with multifocal atrophic gastritis before and 2 year after Helicobacter pylori eradication. Arch. Pathol. Lab Med. 2005. Vol. 129, N 11. P. 1451–1456.
7. Ormerod M.G. [et al.]. Consensus report of the task force on standardization of DNA flow cytometry in clinical pathology. Anal. Cell Pathol. 1998. Vol. 17. Pp.103–110.
8. Correa P. The gastric precancerous process. Cancer Surv. 1983. Vol. 2. Pp. 437–450.
9. Correa P. Human gastric cancerogenesis: a multistep and multifactorial process. Cancer rev. 1992. N 52. Pp. 6735–6740.
10. Lu A.P., Zhang S.S., Zha O.L. [et al.]. Correlatio between CD4,CD8 cell infiltration in gastric mucosa, H. pylori infection and symptoms in patients with chronic gastritis. Wold J. Gastroenterol. 2005. Vol. 28. Pp. 2486–2490.
11. Shankey T.V., Rabinovitch P.S., Bagwell B. [et al.]. Guidelines for implementation of clinical DNA cytometry. Cytometry. 1993. Vol. 14. Pp. 472–477.
12. Smythies L.E., Waites K.B., Lindsey J.R., Harris P.R. Helicobacter pylori–induced mucosal inflammation is TH-1 mediated and exacerbated in IL-4, but not IFN-gamma, genedeficient mice. J. Immunol. 2000. Vоl. 165. Pp. 1022–1029.
13. Brajsa K., Ferencic Z., Katicic M. [et al]. Influence of H.pylori infection and eradication on p53, cerbB-2 and Ki-67 in gastric mucosa. Hepatogastroenterology. 2006 Vol. 53. Pp. 968– 972.
14. Kovama S. Apoptotic depletion of infiltrating mucosal lymphocytes associated with Fas ligand expression by H. pylori-infected gastric mucosal epithelium human glandular stomach as a site of immune privilege. Dig. Dis. Sci. 2000. Vol. 45. Pp. 773–780.
15. Nagayo T. Precursors of human gastric cancer: their frequencies and histological characteristics : Pathophysiol. Carcinogenesis Dig. Org. Proc. 7th Int. Symp. Princess Takamatsu. Cancer Res. Fund. 1977. Рp. 151–160.
16. Niimi C., Ohmiya N.., Niwa Y. [et al.]. Use fullness of p53 and Ki-67 immunohistochemical analysis for preoperative diagnosis of extremely well–differentiated gastric adenocarcinoma. Am. J. Clin. Pathol. 2002. Vol. 118. Pp. 683–692.
Review
For citations:
Davydova N.I., Bychkova V.N., Kobiashvili M.G., Mikhailova I.A. INDICATORS OF TISSUE IMMUNITY IN DIFFERENT TYPES OF FLOW AND CLINICAL OUTCOME OF CHRONIC INFLAMMATION OF THE UPPER GASTROINTESTINAL TRACT. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(1):60-65. (In Russ.) https://doi.org/10.25016/2541-7487-2013-0-1-60-65
Views:
529
Email this article 