ОСНОВНЫЕ МЕХАНИЗМЫ ФОРМИРОВАНИЯ ВНУТРИСУСТАВНОГО ИММУННОГО ОТВЕТА У ПАЦИЕНТОВ С ХЛАМИДИЯ-ИНДУЦИРОВАННЫМ РЕАКТИВНЫМ АРТРИТОМ
https://doi.org/10.25016/2541-7487-2013-0-1-54-59
Abstract
In the review, modern concepts of reactive arthritis (ReA) as immune mediated synovitis due to bacterial infection persisting intra articularly for a long time are considered. The complex mechanisms that lead to the development of ReA, are based on the interaction between the arthritogenic bacterial agent and microorganism. Ability of macroorganism cells to eliminate arthritogenic antigens defined by factors including genetic predisposition (HLA-B27), determine ReA immunopathogenesis. Better understanding of the pathogenetic mechanisms of Chlamydia associated reactive arthritis will facilitate developing the most rational approaches to the treatment of this disease.
About the Authors
A. A. Vetoshkin
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Russian Federation
O. N. Ergashev
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Vetoshkin A.A., Ergashev O.N. . Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(1):54-59. (In Russ.) https://doi.org/10.25016/2541-7487-2013-0-1-54-59
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