TO A QUESTION ON EFFICIENCY OF APPLICATION OF RADIOPROTECTORS WITH VARIOUS MECHANISMS OF ACTION IN INJURES TYPICAL FOR RADIATION ACCIDENTS (EXPERIMENTAL RESEARCH)
https://doi.org/10.25016/2541-7487-2013-0-1-42-47
Abstract
In experiments on rats, influence of preventive administration of sulfur containing radioprotectors (cystamine, gammaphos), agonists of α2 adrenoreceptors (indraline, naphthyzin) and immunomodulators (prodigiosane, betaleukine) on reparative processes in local (due β or X-ray irradiation) and combined radiation injures (general irradiation with superficial or deep radiation skin burns) is investigated. It is established that aminothiols and adrenomimetics show their radioprotective efficiency only in superficial radiation burns, with the most expressed wound healing action for cystamine. In combined radiation injures including superficial skin burns, reparative processes are accelerated when using cystamine, naphthyzin and betaleukine; in injures combined with deep radiation burns – when using cystamine or betaleukine.
About the Authors
V. I. Legeza
Kirov Military Medical Academy, Saint-Petersburg
Russian Federation
Russian Federation
A. N. Grebenyuk
Kirov Military Medical Academy, Saint-Petersburg
Russian Federation
Russian Federation
N. I. Zargarova
Kirov Military Medical Academy, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Legeza V.I., Grebenyuk A.N., Zargarova N.I. TO A QUESTION ON EFFICIENCY OF APPLICATION OF RADIOPROTECTORS WITH VARIOUS MECHANISMS OF ACTION IN INJURES TYPICAL FOR RADIATION ACCIDENTS (EXPERIMENTAL RESEARCH). Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(1):42-47. (In Russ.) https://doi.org/10.25016/2541-7487-2013-0-1-42-47
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