SYSTEMIC INFLAMMATION AND PULMONARY ARTERIAL HYPERTENSION IN CHERNOBYL CLEAN UP WORKERS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
https://doi.org/10.25016/2541-7487-2013-0-1-42-47
Abstract
Mechanisms of diffuse pneumosclerosis and endotheliitis of the pulmonary arteries were assessed in the Chernobyl clean up workers. Radiation (inhalation) lung lesions additionally contributed to systemic inflammation. We investigated the degree of systemic inflammation reflected by circulating levels of C reactive protein (CRP), tumor necrosis factor alpha (TNF ) and interleukin 6 (IL 6) in Chernobyl accident liquidators with chronic obstructive pulmonary disease (COPD) with/without pulmonary arterial hypertension. Increased systolic pulmonary artery pressure (SPPA), which was detected inChernobylclean up workers with COPD more frequently, correlated with higher levels of CRP and TNF . This may indicate a pathogenic role of systemic inflammation in the pathogenesis of pulmonary arterial hypertension in patients with COPD.
About the Authors
I. A. Markova
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg
Russian Federation
Russian Federation
A. D. Komlev
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg
Russian Federation
Russian Federation
A. I. Kuzyaev
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg
Russian Federation
Russian Federation
M. V. Kolosova
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Markova I.A., Komlev A.D., Kuzyaev A.I., Kolosova M.V. SYSTEMIC INFLAMMATION AND PULMONARY ARTERIAL HYPERTENSION IN CHERNOBYL CLEAN UP WORKERS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(1):19-23. (In Russ.) https://doi.org/10.25016/2541-7487-2013-0-1-42-47
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