The effect of accumulation of dioxins in blood lipids on the formation of non-alcoholic fatty liver disease in firefighters

Relevance. During firefighting, in addition to harmful physical factors, there are toxic combustion products, including dioxins – a group of dangerous chemicals capable of accumulating in adipose tissue. At the same time, the first target of dioxins on the path of detoxification of xenobiotics is the liver.

Intention. To identify the features of the formation of non-alcoholic fatty liver disease in firefighters of Federal Fire Service (FFS) of Emercom of Russia, depending on blood lipid concentrations of dioxins.

Methodology. There were examined 121 firefighters (63 of them with fatty liver dystrophy at various stages) and 125 other employees of the Emercom of Russia (65 of them with fatty dystrophy) not involved in firefighting. The indicators of carbohydrate and fat metabolism, dioxins in the blood, metabolic syndrome and some liver parameters were assessed.

Results and Discussion. Based on the analysis, effects of dioxins on the formation of non-alcoholic fatty liver disease indicate different pathogenesis in firefighters vs other employees of the Emercom of Russia not affected by toxic combustion products. Firefighters with non-alcoholic fatty liver disease had significantly lower levels of glucose, insulin resistance index, body mass index and atherogenicity coefficient vs other employees (high values of the above parameters are typical for the metabolic syndrome). At the same time, alanine transaminase activity was higher in firefighters with non-alcoholic fatty liver disease vs other employees, thus indicating greater liver damage.

Conclusion. Based on the results obtained, it can be assumed that non-alcoholic fatty liver disease in firefighters is mainly caused by toxic combustion products, including dioxins.

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