Influence of angiotensin-converting enzyme inhibitors on respiratory muscles in Chernobyl accident liquidators with chronic obstructive pulmonary disease
https://doi.org/10.25016/2541-7487-2014-0-1-52-56
Abstract
In 21 liquidators of the Chernobyl accident aftermath (LCAA) with chronic obstructive pulmonary disease (COPD), strength of respiratory muscles was assessed. It was reduced as compared with the control group. We made attempt to determine whether angiotensin-converting enzyme inhibitors improve respiratory muscle strength in these patients. These patients with stable COPD used perindopril at a dose of 4 mg per day in addition to their standard therapy during 4 months. The following parameters were determined by total body plethysmography: maximum inspiratory pressure (PImax) and maximum expiratory pressure (PEmax), flow rate and volume parameters of respiratory function before and after therapy. Left ventricular ejection fraction (LVEF) and mean pulmonary artery pressure were defined by Doppler echocardiography. The results of our investigation showed (compared with the baseline data) significant increase in PEmax and PImax after therapy with perindopril from (57 ± 27) % of the predicted value to (78 ± 34) %, and from (62 ± 20) to (73 ± 15) %, respectively (p < 0.05). LVEF did not increase significantly (from (54 ± 5) to (57 ± 10) %, p > 0.05); mean pulmonary artery pressure decreased from (27.0 ± 4.1) mm Hg to (22.4 ± 3.5) mm Hg (p < 0.05). There were no changes in the parameters of respiratory function. In LCAA with COPD, long-term treatment with the ACE-inhibitor perindopril improved respiratory muscle strength, which led to significant increase in PImax and PEmax, moderately reduced pulmonary artery pressure and had no effect on lung function.
About the Authors
I. A. Markova
The Nikiforov Russian Center of Emergrency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Head of Pulmonology Department
Russian Federation
Head of Pulmonology Department
M. V. Kolosova
The Nikiforov Russian Center of Emergrency and Radiation Medicine, EMERCOM of Russia
Russian Federation
senior scientist
Russian Federation
senior scientist
A. I. Kuzyaev
The Nikiforov Russian Center of Emergrency and Radiation Medicine, EMERCOM of Russia
Russian Federation
PhD on Med. Sci., senior scientist
Russian Federation
PhD on Med. Sci., senior scientist
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Review
For citations:
Markova I.A., Kolosova M.V., Kuzyaev A.I. Influence of angiotensin-converting enzyme inhibitors on respiratory muscles in Chernobyl accident liquidators with chronic obstructive pulmonary disease. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2014;(1):52-56. (In Russ.) https://doi.org/10.25016/2541-7487-2014-0-1-52-56
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