Integral Assessment of Plasma Hemostasis State in Chernobyl Accident Recovery Workers with Circulatory Diseases

Relevance. High incidence of circulatory diseases in Chernobyl accident recovery workers (ChARW) is closely connected to hemostasis pathology. The introduction of new “global tests” (as they are called) which assess plasma hemostasis state brings about the additional opportunities for diagnostics of hypercoagulability syndrome (HS) as a risk factor of thrombotic complications at circulatory diseases.
Intention. The objective of the work is to study the state of plasma hemostasis system in ChARW with circulatory diseases using method of thrombodynamics (TD).
Methods. 140 male ChARW, aged 44 to 82, diagnosed with discirculatory encephalopathy, ischemic heart disease, essential hypertension were examined. All patients underwent complex clinical, instrumental and laboratory studies. TD test (TD recorder, by HemaCore, Russia) showed the lag-time for the beginning of clot formation (Tlag, min.), rate of clot growth (V, um/min.), spontaneous clots formation time (Tsp, min.) and some other additional parameters: initial rate of clot growth (Vi, um/min.), fibrin clot size (CS, um)and its density (D, a.u.).
Results and discussion. The obtained results demonstrate HS formation in ChARW with circulatory diseases. This group of patients is characterized with considerable increase of fibrin clot growth rate (V) and spontaneous clots formation within the measuring area at distance of clot activator (Tsp), i.e. the increase of those TD test parameters which are more sensitive to microvesicles formed at thrombocytes activation. TD tests parameters have been related to the applied antiaggregant therapy, brachiocephalic artery atherosclerosis and diabetes mellitus.
Conclusion. TD method improves considerably the opportunities of the laboratory diagnostics in HS detection in patients with circulatory diseases.

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