EVALUATION OF GENOTOXIC EFFECTS OF MYCOTOXINS IN VIVO USING DNA COMET ASSAY
https://doi.org/10.25016/2541-7487-2013-0-2-63-66
Abstract
Mycotoxins zearalenone, aflatoxin B1 and ochre toxin A are the most common contaminants of food and feed, and have genotoxic and carcinogenic properties. Comet assay was used to study combined genotoxic effects of aflatoxin B1 (0.0257 mg), ochratoxin A (0.0128 mg) and zearalenone (0.0064 mg) in vivo in the cells of the bone marrow and blood leu kocytes of Wistar rats at 15 , 30 and 60 day treatment. Genotoxic activity of the studied mycotoxins was revealed. It was most pronounced in blood leukocytes after 60 day treatment and in bone marrow cells also after a 30 day treatment. It is shown that rat bone marrow cells compared with blood leukocytes are much more sensitive to the action of the mycotoxin combination under study.
About the Authors
T. A. Arutyunyan
Yerevan State University
Armenia
Armenia
R. M. Arutyunyan
Yerevan State University
Armenia
Armenia
G. G. Oganesyan
Yerevan State University
Armenia
Armenia
A. F. Karapetyan
Yerevan State University
Armenia
Armenia
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Review
For citations:
Arutyunyan T.A., Arutyunyan R.M., Oganesyan G.G., Karapetyan A.F. EVALUATION OF GENOTOXIC EFFECTS OF MYCOTOXINS IN VIVO USING DNA COMET ASSAY. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(2):63-66. (In Russ.) https://doi.org/10.25016/2541-7487-2013-0-2-63-66
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