Functional and ultrasound changes in the liver and pancreas in servicemen with initial atherosclerosis

Relevance. Diseases associated with atherosclerosis such as cerebrovascular diseases, ischemic heart disease, lesions of blood vessels of the kidneys and extremities significantly decrease professional longevity of servicemen. Their lifestyles are often more active than in civilians, however younger servicemen have suffered from these nosological forms over past decades. Intention. To assess clinical, ultrasound and biochemical parameters of the liver and pancreas in young and middle-aged servicemen with initial manifestations of atherosclerosis. Methods. 158 servicemen of (37.8 ± 5.5) years underwent in-depth examination. Along with conventional risk factors of cardiovascular diseases, apolipoproteins A and B, hepatic transaminases, and ultrasound indices of the liver, pancreas and vascular wall were studied. Results and Discussion. Based on clinical and laboratory-instrumental data, 3 groups were identified: Group 1 – 61 men with subclinical atherosclerosis and pancreas and hepatobiliary lesions; Group 2 – 32 men with isolated initial atherosclerosis of carotid arteries; Group 3 (controls) – 65 otherwise healthy men without overt cardiovascular, pancreas and hepatobiliary pathology. Group 1 had the worst cardiovascular anamnesis, alimentary status, glycemic profile and early remodeling of left atrium. Conclusion. A prognostic model of the nonalcoholic fatty liver and pancreas disease was developed using such markers as obesity duration, waist circumference and endothelium thickness. Morphological changes in the liver and pancreas of the young men with initial manifestations of atherosclerosis are accompanied with concealed dysfunction of these organs manifested as early post-load hyperglycemia and dyslipidemia with considerably increased long-term risk of type 2 diabetes mellitus and cardiovascular complications.

servicemen, military medicine, initial atherosclerosis, fatty liver, nonalcoholic fatty pancreas disease, cardiovascular risk factor, lipid and carbohydrate metabolism, young men

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