Capabilities laboratory diagnostics in the detection of osteopenia and osteoporosis at outpatient stage
https://doi.org/10.25016/2541-7487-2015-0-3-62-66
Abstract
200 outpatient firefighters of the State fire service of EMERCOM of Russia at the age from 21 to 45 years were examined. Evaluation of mineral bone density (BMD) has allowed firefighters to be distributed into groups: group 1 (42.5 %) with normal BMD (variability from +2.5 to –1 SD), 2 (50 %) with osteopenia (–1 to –2.5 SD), 3 (7,5 %) with osteoporosis (–2.5 SD or less). The decrease in BMD in different regions of the skeleton was uneven, mainly observed in the lumbar spine and proximal femur; to a lesser extent, in the region of the forearm. The dependence of changes in laboratory parameters on the speed and direction of metabolic processes in the bone tissue of the examined patients was shown. Reduced BMD is accompanied by a high level of resorption marker Dpyr/Cr and remodeling – osteocalcin. Increased Dpyr/Cr was associated with lower BMD of the skeleton and pathology of the hard tissues of the teeth. Thus, the higher was the concentration of Dpyr/Cr, the more extracted teeth were detected (r = 0.346; p < 0.05). An inverse relationship was typical for periodontal tissues. Along with the reduction of BMD indices signs of inflammation in the gingival tissues increased: correlation of BMD and index PI (r = –0.547; p < 0.01); BMD index and CI (r = –0.551; p < 0.01). The high degree of correlation between tooth mobility with reduced BMD (r = –0.479; p < 0.05) was noted. We found a significant relationship between Dpyr/Cr and index PMA (r = 0.382; p < 0.05). It can be concluded that the level of Dpyr/Cr reflects the activity of the pathological process not only in the bone tissue of the skeleton, but also in the mineralized tissues of the teeth and gingival tissues – soft tissue consisting of collagen fibers, and alveolar bone. It is shown that the specific bone biomarkers complement existing technologies to determine the mineral density of bone tissue. Information about the phases of bone remodeling can be obtained at the outpatient stage of firefighters examination.
About the Authors
L. B. Drygina
The Nikiforov Russian Center of Emergency and Radiation Medicine EMERCOM of Russia
Russian Federation
Russian Federation
Dr Biol. Sci. Prof., Head of the Laboratory, the Nikiforov Russian Center of Emergency and Radiation Medicine EMERCOM of Russia (Russia, 194044, Saint- Petersburg, Academica Lebedeva Str., 4/2)
N. A. Dorofeichik-Drygina
The Nikiforov Russian Center of Emergency and Radiation Medicine EMERCOM of Russia
Russian Federation
Russian Federation
Ortodont, Head of the Policlinic, the Nikiforov Russian Center of Emergency and Radiation Medicine EMERCOM of Russia (Russia, 194044, Saint- Petersburg, Academica Lebedeva Str., 4/2)
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For citations:
Drygina L.B., Dorofeichik-Drygina N.A. Capabilities laboratory diagnostics in the detection of osteopenia and osteoporosis at outpatient stage. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2015;(3):62-66. (In Russ.) https://doi.org/10.25016/2541-7487-2015-0-3-62-66
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