Experimental study of glutathione disulfide organic salt and inosine hemostimulating activity mechanisms in conditions of acute radiation exposure

In experiments on mice exposed to acute external gamma radiation, hemostimulating activity mechanisms of glutathione disulfide organic salt and inosine – the medicament molixan — were studied. Molixan was administered intraperitoneally at a dose of 30 mg / kg 1 time a day for 10 days after irradiation. It was found that irradiation at a dose of 3.5 Gy caused the death of 30 % of the mice, and molixan reduced mortality in irradiated animals to 10 %. The ability of molixan to accelerate post-radiation recovery of bone marrow hematopoiesis by stimulating myelocytic and megakaryocytic cell lines was demonstrated, with resulting increase in the number of white blood cells and platelets in the peripheral blood. Hemostimulating activity of molixan can be mediated by increased production of hematopoietic cytokines– interleukin-1, interleukin-2, interleukin-6, granulocyte-macrophage and granulocyte colony-stimulating factors – by splenocytes.

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