PHARMACOLOLOGICAL CORRECTION OF ADAPTIVE REACTIONS OF CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS IN WORKERS OF HIGH-MOUNTAIN MINE WORKING ON A ROTATIONAL BASIS
https://doi.org/10.25016/2541-7487-2013-0-4-76-81
Abstract
Effectiveness of preparations of actoprotectors class prescribed to correct adaptation processes in cardiovascular and central nervous systems was assessed in miners of Kumtor high-mountain mine working on a rotational basis. 58 miners (male drillers and miners aged 19-45 years) working constantly at the main production site took part in this randomized controlled trial. They were divided into three groups. The first group of 25 men took placebo, the second group of 15 men took metaprote at a dose of0,125 g(preparation with adaptogenic action from mercaptobenzimidazole class, Pharmproject Closed Corporation, St. Petersburg), and the third group of 18 men took metaprote at a dose of0,25 gtogether with ladasten at a dose of0,100 g(antiasthenic remedy, adamantane derivative, Lekko Pharmaceutical Firm, Vladimirskaya obl., Petushinski region, Volginski settlement). Drugs were administered three times per shift on Day 2, 7 and 13 one hour before examination. It is established that study drugs facilitate adaptation of cardiovascular and central nervous systems. In «placebo» group, no complete adaptation of cardiovascular and central nervous systems is observed at the end of the second week of shift. Metaprote accelerates the adaptation of cardiovascular system, but psychophysiological state is characterized by decreased vigilance level. The combined intake of metaprote with ladasten provides optimal functional state of cardiovascular system already on shift day 1 and psychophysiological state at the end of shift week 1.
About the Authors
U. K. Kundashev
I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek
Kyrgyzstan
Kundashev Ulan Kel'ginovich - Ph, Associate Prof. the Department of Clinical Pharmacology
Kyrgyzstan
Kundashev Ulan Kel'ginovich - Ph, Associate Prof. the Department of Clinical Pharmacology
A. Z. Zurdinov
I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek
Kyrgyzstan
Zurdinov Alishari Zurdinovich - DM, Prof. Rector
Kyrgyzstan
Zurdinov Alishari Zurdinovich - DM, Prof. Rector
U. S. Morozov
Russian Federation
Morozov Igor' Sergeevich - DM, Prof.
V. G. Barchukov
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Barchukov Valerij Gavrilovich - DM, Prof. the Department of Medicine of Catastrophes
Russian Federation
Barchukov Valerij Gavrilovich - DM, Prof. the Department of Medicine of Catastrophes
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Review
For citations:
Kundashev U.K., Zurdinov A.Z., Morozov U.S., Barchukov V.G. PHARMACOLOLOGICAL CORRECTION OF ADAPTIVE REACTIONS OF CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS IN WORKERS OF HIGH-MOUNTAIN MINE WORKING ON A ROTATIONAL BASIS. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(4):76-81. (In Russ.) https://doi.org/10.25016/2541-7487-2013-0-4-76-81
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