. EXPERIENCE OF DIAGNOSIS AND MONITORING OF CRITICAL HEMOSTASIS DISORDERS
https://doi.org/10.25016/2541-7487-2013-0-4-55-60
Abstract
The aim of the study was to demonstrate the practical use of «global» laboratory test - low- frequency piezothromboelastography in assessing and monitoring hemostatic disorders in critical conditions (hemorrhagic shock, posttraumatic thrombosis and hemorrhagic complications). Technology of low-frequency piezothromboelastography in «point - of - care test» mode provides information on all three phases of coagulation with an integrative assessment of the state of vascular-platelet, coagulation, anticoagulant components of hemostasis and total fibrinolytic activity. It is shown that the evaluation of hemostatic potential of whole blood - the integrative activity of vascular-platelet, coagulation, fibrinolytic and anticoagulant hemostasis defining actual rheological properties of blood and its ability to limit extravasation of cellular and liquid components when vascular wall is damaged using low-frequency piezothromboelastography makes it possible to reveal critical hemostatic disorders and develop adequate approach for their correction
About the Authors
M. A. Soloviev
Institute of pharmacology E.D. Goldberg of Tomsk scientific center of Siberian department of Russian academy of medical sciences
Russian Federation
Solov'ev Maksim Аleksandrovich - Ph, attending physician offices drug monitoring
Russian Federation
Solov'ev Maksim Аleksandrovich - Ph, attending physician offices drug monitoring
I. I. Tyutrin
Siberian State Medical University, Tomsk
Russian Federation
Tyutrin Ivan Illarionovich - DM, Prof., Department of Anesthesiology and Intensive Care
Russian Federation
Tyutrin Ivan Illarionovich - DM, Prof., Department of Anesthesiology and Intensive Care
V. V. Udut
The institute of pharmacology E.D. Goldberg of Tomsk scientific center of Siberian department of Russian academy of medical sciences
Russian Federation
Udut Vladimir Vasil'evich - DM, Prof., Physiology Laboratory, Molecular and Clinical Pharmacology, member of the Russian Academy of Medical Science
Russian Federation
Udut Vladimir Vasil'evich - DM, Prof., Physiology Laboratory, Molecular and Clinical Pharmacology, member of the Russian Academy of Medical Science
V. F. Klimenkova
Regional Perinatal Center, Tomsk
Russian Federation
Klimenkova Valentina Fedorovna - doctor
Russian Federation
Klimenkova Valentina Fedorovna - doctor
References
1. Gel'fand B.R., Gologorskii V.A., Burnevich S.3. Selektivnaya dekontaminatsiya i detoksikatsiya zheludochno-kishechnogo trakta v neotlozhnoi abdominal'noi khirurgii i intensivnoi terapii [Selective decontamination and detoxification of the gastrointestinal tract in emergency abdominal surgery and intensive care]. Vestnik intensivnoi terapii [Intensive care herald]. 1995. N 1. Pp. 8–11. (In Russ.)
2. Gumanenko E.K., Nemchenko N.S., Boyarintsev V.V. Narusheniya v sisteme gemostaza pri tyazhelykh raneniyakh i travmakh [Hemostatic disorders in severe wounds and injuries]. SanktPeterburg. 2006. 94 p. (In Russ.)
3. Zil'ber A.P. Poliorgannaya nedostatochnost' kak novyi vid patologii: klinicheskaya fiziologiya, intensivnaya terapiya, profilaktika [Multiple organ failure as a new kind of pathology: clinical physiology, intensive care, prevention]. Aktual'nye problemy meditsiny kriticheskikh sostoyanii [Actual problems of critical care medicine]. 2000. N 7. Pp. 71–91. (In Russ.)
4. Leiderman I.N. Sindrom poliorgannoi nedostatochnosti (PON). Metabolicheskie osnovy (part 1) [Multiple organ dysfunction syndrome (MODS). Metabolic basis (part 1).]. Vestnik intensivnoi terapii [Intensive care herald]. 1999. N 2. Pp. 8–13. (In Russ.)
5. Rudnov V.A. Infuzionno-transfuzionnaya terapiya kak komponent intensivnoi terapii sepsisa [Infusion-transfusion therapy as a component of intensive therapy for sepsis]. Consilium medicum. Surgery (application). 2005. N 1. Pp. 54–57. (In Russ.)
6. Tyurin I.I., Udut V.V, Shpisman M.N., Nizkochastotnaya p'ezotromboelastografiya v diagnostike gemostaziologicheskikh rasstroistv [Low-frequency piezothromboelastography in diagnosing hemostatic disorders]. Tomsk. 2013. Pp. 5–8. (In Russ.)
7. Udut V.V., Tyutrin I.I. Novye tekhnologii otsenki effektivnosti antitromboticheskikh lekarstvennykh sredstv [New technologies to evaluate the effectiveness of antithrombotic drugs.]. Tezisy dokladov XXII s"ezda fiziologicheskogo obshchestva imeni I.P. Pavlova [Abstracts of XXII Congress of Physiological Society named after I.P. Pavlov]. Volgograd. 2013. Pp. 535. (In Russ.)
8. Mazurkevich G.S. [et al.]. Shok : teoriya, klinika, organizatsiya protivoshokovoi pomoshchi [Shock: theory, manifestations and organization antishock care]. Sankt-Peterburg. 2004. 538 p. (In Russ.)
Review
For citations:
Soloviev M.A., Tyutrin I.I., Udut V.V., Klimenkova V.F. . EXPERIENCE OF DIAGNOSIS AND MONITORING OF CRITICAL HEMOSTASIS DISORDERS. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(4):55-60. (In Russ.) https://doi.org/10.25016/2541-7487-2013-0-4-55-60
Views:
463
Email this article 