LEVELS OF AUTOANTIBODIES TO NR2A SUBUNIT OF NMDA GLUTAMATE RECEPTORS AS AN OBJECTIVE CRITERION FOR THE EFFICIENCY OF CEREBRAL BLOOD FLOW IN PATIENTS WITH ISCHEMIC BRAIN DISORDERS
https://doi.org/10.25016/2541-7487-2013-0-4-48-54
Abstract
The study included 92 patients with hemodynamically significant stenosis of the internal carotid artery, which were divided into 2 groups: 1st - with sufficient structural and functional potential for compensation of cerebral blood flow, 2nd - low structural and functional potential for compensation of cerebral blood flow. Retrospective immunoenzyme method of semiquantitative determination of antibodies to NR2A subunit of NMDA glutamate receptors was used. It was found that in group 2 patients alteration of NMDA glutamate receptors prevailed. Deterioration of cerebral blood flow for a period ofICAclamping during surgery is a factor objectively aggravating hypoxia in the affected vascular region and enhancing the degree of alteration of NMDA glutamate receptors. At the same time, the longer theICAclamping, the higher the degree of destructive effects on NMDA glutamate receptors through mechanisms of excitotoxicity.
About the Authors
V. N. Ochkolyas
First Pavlov State Medical University of St. Peterburg
Russian Federation
Ochkolyas Vladislav Nikolaevich - Ph, senior lecturer of neurology and neurosurgery Department with Clinic
Russian Federation
Ochkolyas Vladislav Nikolaevich - Ph, senior lecturer of neurology and neurosurgery Department with Clinic
G. Y. Sokurenko
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Russian Federation
Sokurenko German Yurjevich - MD, Prof., Head Physician of Clinic N 2
Russian Federation
Sokurenko German Yurjevich - MD, Prof., Head Physician of Clinic N 2
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Review
For citations:
Ochkolyas V.N., Sokurenko G.Y. LEVELS OF AUTOANTIBODIES TO NR2A SUBUNIT OF NMDA GLUTAMATE RECEPTORS AS AN OBJECTIVE CRITERION FOR THE EFFICIENCY OF CEREBRAL BLOOD FLOW IN PATIENTS WITH ISCHEMIC BRAIN DISORDERS. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(4):48-54. (In Russ.) https://doi.org/10.25016/2541-7487-2013-0-4-48-54
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